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  • Maria J Smolinska, Nicole J. Horwood, Theresa H. Page, Tim Smallie, Brian M. J. Foxwell
  • Biology, Medicine
  • Molecular immunology
  • 2008 (First Publication: 1 February 2008)
  • Understanding the signalling mechanisms controlling inflammatory cytokine production is pivotal to the research of both acute and chronic immune disorders. Tyrosine phosphorylation is one of theContinue Reading
  • Tim Smallie, Giuseppe Ricchetti, Nicole J. Horwood, Marc Feldmann, Andrew R Clark, Lynn M. Williams
  • Biology, Medicine
  • The Journal of experimental medicine
  • 2010 (First Publication: 27 September 2010)
  • IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms involved remain to be resolved. Using primary human macrophages, we found that IL-10 inhibitsContinue Reading
  • Lynn M. Williams, Ushā Śarmā, Kate Willets, Tim Smallie, Fionula Brennan, Brian M. J. Foxwell
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2007 (First Publication: 9 March 2007)
  • There is general agreement that signal transducer and activation of transcription 3 (STAT3) is required to mediate the anti-inflammatory activities of interleukin (IL)-10. However, STAT3 is activatedContinue Reading
  • Tina M Y Tang, T. E. Scambler, +5 authors Andrew R Clark
  • Biology, Medicine
  • Scientific Reports
  • 2017 (First Publication: 28 June 2017)
  • In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to aContinue Reading
  • Rachel E Simmonds, Ferdinand V. Lali, Tim Smallie, Pamela L. C. Small, Brian M. J. Foxwell
  • Medicine, Biology
  • The Journal of Immunology
  • 2009 (First Publication: 15 February 2009)
  • The virulence and immunosuppressive activity of Mycobacterium ulcerans is attributed to mycolactone, a macrolide toxin synthesized by the bacteria. We have explored the consequence and mechanism ofContinue Reading