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Expert recommender systems (ERS) are considered a promising technology in knowledge management. However, there are very few studies which evaluated their appropriation in practice. In this paper, we present results of a case study of expert recommender technology in a large European industrial association. Unlike existing expert recommender approaches, the(More)
The term knowledge management (KM) has lost most of its magic during the past few years: While knowledge has been identified as an important resource and key factor for productivity gains and innovation in organizations, there seems to be no generally applicable (and easy) way to utilize this resource. In this paper we present results of a field study that(More)
The adenomatous polyposis coli (APC) tumor suppressor is a major regulator of the Wnt signaling pathway in normal intestinal epithelium. APC, in conjunction with AXIN and GSK-3beta, forms a complex necessary for the degradation of beta-catenin, thereby preventing beta-catenin/T-cell factor interaction and alteration of growth-controlling genes such as c-MYC(More)
RATIONALE Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases. OBJECTIVES To define changes in gene expression profiles during in vivo rhinovirus infections. METHODS Nasal epithelial scrapings were obtained before and during experimental rhinovirus infection, and gene expression was evaluated by microarray.(More)
Recent knowledge management initiatives focus on expertise sharing within formal organizational units and informal communities of practice. Expert recommender systems seem to be a promising tool in support of these initiatives. This paper presents experiences in designing an expert recommender system for a knowledge-intensive organization, namely the(More)
Bringing together human actors with similar interests, skills or expertise is a major challenge in community-based knowledge management. We believe that writing or reading textual documents can be an indicator for a human actor's interests, skills or expertise. In this paper, we describe an approach of matching human actors based on the similarity of text(More)
BACKGROUND To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS Gingival biopsy samples collected from 14 subjects during a 28-day stent-induced experimental gingivitis model,(More)
Zinc pyrithione (ZPT) is an antimicrobial material with widespread use in antidandruff shampoos and antifouling paints. Despite decades of commercial use, there is little understanding of its antimicrobial mechanism of action. We used a combination of genome-wide approaches (yeast deletion mutants and microarrays) and traditional methods (gene constructs(More)
Learning platform focus often on content presentation. Collaborative aspects are mostly dealt with by providing functionality to annotate parts of the content or discuss with other learners about the content. Nowadays learning platforms do not support systematically match making processes among those actors who are able to support their individual learning(More)