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Our study was designed to determine whether intrastriatal administration of glial cell line-derived neurotrophic factor (GDNF) can attenuate the behavioral effects and injury to the mesostriatal dopaminergic system caused by 6-hydroxydopamine (6-OHDA). Four groups of rats received a series of four intrastriatal injections of vehicle or one of three doses of(More)
Groups of eight rats received unilateral, intrastriatal injections of 22.5 micrograms brain-derived neurotrophic factor (BDNF) or cytochrome c on 3 consecutive days. Following the injection of BDNF or cytochrome c on the second day, each animal received an intrastriatal injection of 25 micrograms of 6-hydroxydopamine (6-OHDA). During the second week(More)
Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neuroprotective influence in neurons,(More)
The distribution of nerve growth factor-inducible large external (NILE) glycoprotein in the developing mesostriatal dopaminergic system was studied by immunolabeling prenatal, postnatal, and adult rat brains for both NILE and tyrosine hydroxylase (TH). NILE-immunoreactive (NILE-IR) material outlined the TH-immunoreactive (TH-IR) neurons in the ventral(More)
At P0, P2 and P3, islands of increased density of Thy-1-immunoreactive (Thy-1-IR) material, which coincided with the islands of dense dopaminergic axons, were noted in the striatum. By P5, the distribution of Thy-1-IR material was homogeneous throughout the developing striatum, but islands of dense dopaminergic axons persisted. The pattern of appearance of(More)
In the developing mesencephalon of the rat, the dopaminergic neurons are generated in the ventricular zone of the basal plate between E11 and E15 and then migrate along radial glia to the ventral surface of the developing mesencephalon. To study the factors that control migration and maturation of the dopaminergic neurons, we immunolabeled embryo and pups,(More)
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