Tim Hulsen

Philips Research, NV Organon, Radboud University Nijmegen
0000-0002-0208-8443
http://tim.hulsen.net
Publications36
h-index10
Citations1,807
Highly Influential Citations93
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BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams
TLDR
BioVenn is an easy-to-use web application to generate area-proportional Venn diagrams from lists of biological identifiers, which supports a wide range of identifiers from the most used biological databases currently available.
Benchmarking ortholog identification methods using functional genomics data
TLDR
By combining the sensitivity and the selectivity into an overall score, it is shown that the InParanoid program is the best ortholog identification method in terms of identifying functionally equivalent proteins.
Identification of novel functional TBP‐binding sites and general factor repertoires
TLDR
This study broadens the spectrum of general transcription factor function and uncovers a plethora of novel, functional TATA‐binding protein (TBP)‐binding sites in the human genome.
From Big Data to Precision Medicine
TLDR
Both the opportunities and challenges posed to biomedical research by the increasing ability to tackle large datasets are discussed, including the need for standardization of data content, format, and clinical definitions.
Testing statistical significance scores of sequence comparison methods with structure similarity
TLDR
Two out of three Smith-Waterman implementations with e-value are better at predicting structural similarities between proteins than the Smith- waterman implementation with Z-score, and the compute intensive Z- score does not have a clear advantage over the e- value.
Evolution of closely linked gene pairs in vertebrate genomes.
TLDR
It is shown here that a lack of head-to-tail (h2t) gene duos is an even more distinctive characteristic of mammalian genomes, with the platypus genome as the only exception.
PhyloPat: an updated version of the phylogenetic pattern database contains gene neighborhood
TLDR
This work used a single linkage clustering algorithm to create 241 697 phylogenetic lineages, using all the orthologies provided by Ensembl v49, and described an updated version of PhyloPat which can be queried by an improved web server.
Heavier‐than‐air flying machines are impossible
Sharing Is Caring—Data Sharing Initiatives in Healthcare
  • Tim Hulsen
  • Medicine, Political Science
    International journal of environmental research…
  • 27 April 2020
TLDR
An analysis of the current literature around data sharing is shown, and five aspects of data sharing in the medical domain are discussed: publisher requirements, data ownership, growing support for data sharing, data sharing initiatives and how the use of federated data might be a solution.
PhyloPat: phylogenetic pattern analysis of eukaryotic genes
TLDR
PhyloPat is the first tool to combine complete genome information with phylogenetic pattern querying and is presented, which allows the complete Ensembl gene database to be queried using phylogenetic patterns.
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