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Imaging Evaluation of 5HT2C Agonists, [11C]WAY-163909 and [11C]Vabicaserin, Formed by Pictet–Spengler Cyclization
The serotonin subtype 2C (5HT2C) receptor is an emerging and promising drug target to treat several disorders of the human central nervous system. In this current report, two potent and selectiveExpand
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Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
In this study, we disclose the design and synthesis of novel 4-susbtituted nipecotic acid derivatives as inhibitors of the GABA transporter mGAT1. Based on molecular modeling studies the compoundsExpand
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Conjugate Addition of Organomagnesium Cuprates to Guvacine Derivatives
The synthesis of 4-substituted piperidine-3-carboxylates was achieved by conjugate addition of organomagnesium cuprates to N-methyl and N-tert-butoxycarbonyl guvacine derivatives. Good to excellentExpand
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