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  • Gautam Borthakur, Hervé Dombret, +9 authors Jorge E. Cortes
  • Medicine
  • Haematologica
  • 17 April 2015
  • Danusertib is a pan-aurora kinase inhibitor with potent activity against Abl kinase including the gatekeeper T315I mutant. A phase 1 dose escalation study of danusertib was conducted in patients withContinue Reading
  • Ioakim Spyridopoulos, Young Erben, +9 authors Stefanie Dimmeler
  • Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 May 2008
  • OBJECTIVE We have previously demonstrated that ischemic cardiomyopathy is associated with selective impairment of progenitor cell function in the bone marrow and in the peripheral blood, which mayContinue Reading
  • Jan B Vermorken, Joël Guigay, +6 authors Tim H Brummendorf
  • Medicine
  • British Journal of Cancer
  • 1 May 2011
  • Background:Novel therapies are needed to improve the poor prognosis of patients with recurrent and/or metastatic squamous cell cancer of the head and neck (SCCHN).Methods:ADVANTAGE is a phase I/II,Continue Reading
  • Jorge E Cortes-Franco, Hervé Dombret, +6 authors Silvia Comis
  • Medicine
  • 20 November 2009
  • Abstract 864 Background: Despite the availability of novel ABL tyrosine kinase inhibitors ( TKI ) in addition to imatinib mesylate, the acquisition of the T315I BCR-Abl mutation remains a major causeContinue Reading
  • Carlo Gambacorti‐Passerini, Jorge E. Cortes, +7 authors Tim H Brummendorf
  • Medicine
  • Journal of clinical oncology : official journal…
  • 20 May 2011
  • 6509 Background: The phase 3 BELA study compared BOS (competitive dual Src/Abl kinase inhibitor) with IM in newly diagnosed CP CML. METHODS 502 pts with CP CML stratified by Sokal score and regionContinue Reading
  • Evgeny Klyuchnikov, Nicolaus Kröger, Tim H Brummendorf, Bettina Wiedemann, Axel Rolf Zander, Ulrike Bacher
  • Medicine
  • Biology of blood and marrow transplantation…
  • 1 March 2010
  • Following the introduction of tyrosine kinase inhibitors (TKIs) in chronic myelogenous leukemia (CML), allogeneic stem cell transplantation (SCT) took a shift toward high-risk patients. ConsideringContinue Reading
  • Tim H Brummendorf, Inci Ersoz, +15 authors Andreas Hochhaus
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 May 2003
  • Telomeres are composed of TTAGGG repeats and associated proteins. In somatic cells, telomere repeats are lost with each cell division, eventually leading to genetic instability and cellularContinue Reading