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Microwave-assisted chemical phosphitylation of novel nucleoside analogs containing a ribulose sugar unit was successful with yields ranging from 50% to 79% using 2-cyanoethyl-N,N-diisopropyl chlorophosphoramidite as the phosphitylating reagent. The resultant phosphoramidite products remained intact, with no signs of degradation over extended reaction times… (More)
The author underlines how important it is not to neglect an organical illness, particularly if the patient is of age since it is easy to diagnosticate a depression. He enumarates the various complementary examinations which, combined to a clinical one would allow to reject an organical cause.
Microwave-assisted phosphitylation of sterically hindered nucleosides is demonstrated to be an efficient method for the preparation of corresponding phosphoramidites (otherwise onerous under standard conditions) and is shown to be general in its applicability.
A case of incomplete rupture of the extensor tendon to the little finger is reported in a 64-year-old woman with an idiopathic Madelung's deformity which had been present since adolescence but had given rise to no problems. Surgical treatment by resection of the head of the ulna with fixation of the ulna to the radius gave a satisfactory result. Only two… (More)