Tim C Elston

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Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the treatment of human disease. However, the(More)
Extracellular nucleotides are key components of the signaling network regulating airway clearance. They are released by the epithelium into the airway surface liquid (ASL) to stimulate cilia beating activity, mucus secretion and airway hydration. Understanding the factors affecting their availability for purinoceptor activation is an important step toward(More)
The dynamics of two simple neuron models subjected to periodic stimuli is studied at the level of the first passage time probability density. The results from analytic treatments of these models are presented, and a discussion of the important properties displayed by these models is given. Specifically, both models possess resonans phenomena in the first(More)
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