Tijs Louwies

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Exposure to ambient particulate matter and elevated blood pressure are risk factors for cardiovascular morbidity and mortality. Microvascular changes might be an important pathway in explaining the association between air pollution and blood pressure. The objective of the study was to evaluate the role of the retinal microcirculation in the association(More)
Methods 225 children (49% girls; mean age 9.9 years) were recruited at two primary schools in Belgium. Participating children were examined three times at school over the course of the school year, during which the fundus of both eyes was photographed. The caliber of the retinal blood vessels was summarized as the central retinal arteriolar/venular(More)
BACKGROUND Microcirculation plays an important role in the physiology of cardiovascular health. Air pollution is an independent risk factor for the development and progression of cardiovascular diseases, but the number of studies on the relation between air pollution and the microcirculation is limited. OBJECTIVES We examined the relationship between(More)
BACKGROUND Daily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnerable target. METHODS To evaluate the association between daily changes in air pollution and lung function in healthy adults we obtained(More)
The microcirculation consists of blood vessels with diameters less than 150 µm. It makes up a large part of the circulatory system and plays an important role in maintaining cardiovascular health. The retina is a tissue that lines the interior of the eye and it is the only tissue that allows for a non-invasive analysis of the microvasculature. Nowadays,(More)
BACKGROUND Vascular changes may underpin the association between airborne black carbon (BC) and cardiovascular events. Accurate assessment of personal exposure is a major challenge in epidemiological research. BC concentrations are strongly related to time-activity patterns, which is particularly relevant when investigating short-term effects. We(More)
Air pollution, a cardiovascular risk factor, might exert its effects through the microcirculation. Fundus photography allows study of the retinal vasculature in vivo. Short-term PM10 exposure is associated with changes in retinal blood vessels, but the underlying mechanism remains unknown. Expression of MIR21, MIR222 and MIR146A, gene regulators involved in(More)
Purpose To assess the separate and combined effects of exposure to prolonged and sustained recumbency (bed rest) and hypoxia on retinal microcirculation. Methods Eleven healthy male subjects (mean ± SD age = 27 ± 6 years; body mass index [BMI] = 23.7 ± 3.0 kg m-2) participated in a repeated-measures crossover design study comprising three 21-day(More)
BACKGROUND Microvascular changes may represent an underlying mechanism through which exposure to fine particulate matter with a diameter ≤ 2.5µm (PM2.5) contributes to age-related disease development. We investigated the effect of recent and chronic exposure to PM2.5 on the microcirculation, exemplified by retinal vessel diameters, using repeated(More)
INTRODUCTION Air pollution, a risk factor for cardiovascular diseases, can exert its effects through the microcirculation. Retinal blood vessel width is considered a marker for microvascular health and is associated with short-term PM10 exposure. microRNAs are key regulators of complex biological processes in cardiovascular health and disease and miRNA(More)
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