Tiina Lyyra-Laitinen

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The paper considers the intensity modulated radiation therapy (inverse) treatment planning. An approach to determine the trajectories of the leaves of the multileaf collimator (MLC) in order to produce the prescribed intensity distribution is developed. The paper concentrates on the multiple static delivery technique. A mathematical model for calculating(More)
BACKGROUND The purpose of the present study was to investigate pregnancy-related changes in the maternal serum lipid profile and endothelial function. METHODS AND RESULTS As part of the population-based, prospective cohort Cardiovascular Risk in Young Finns study conducted in Finland, 57 pregnant Finnish women and 62 control women matched for age and(More)
The time interval between Q-wave onset and T-wave offset, i.e., QT interval, in an ECG corresponds to the total ventricular activity, including both depolarization and repolarization times. It has been suggested that abnormal QT variability could be a marker of cardiac diseases such as ventricular arrhythmias, and QT-interval has also been observed to(More)
BACKGROUND The aim was to evaluate the metabolic profile in conjunction with vascular function using the ambulatory arterial stiffness index (AASI) in women with uncomplicated pregnancies and in women with gestational diabetes mellitus (GDM). METHODS Plasma glucose, lipids, HOMA -IR (homeostasis model assessment of insulin resistance) and AASI, as(More)
Background. Our objective was to evaluate endothelial function and markers of inflammation during and after pregnancy in normal pregnancies compared to pregnancies complicated with hypertension or preeclampsia (PE). Methods and Results. We measured endothelium-dependent brachial artery flow-mediated vasodilation (FMD) and high sensitive C-reactive protein(More)
Ventricular repolarization duration (VRD) is controlled by neural regulatory system same way as heart rate and, thus, also VRD varies in time. VRD variability is commonly assessed by determining the time differences between successive R and T-waves, i.e. RT intervals. Traditional methods for RT interval detection necessitate the detection of either T-wave(More)
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