Tihana Harrison

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Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini, respectively, of the A beta amyloidogenic peptides A beta40 and A beta42--the major constituents of the amyloid plaques in the brain parenchyma of Alzheimer's disease patients. There is evidence that the polytopic membrane-spanning(More)
Intramembranous cleavage of the beta-amyloid precursor protein by gamma-secretase is the final processing event generating amyloid-beta peptides, which are thought to be causative agents for Alzheimer's disease. Missense mutations in the presenilin genes co-segregate with early-onset Alzheimer's disease, and, recently, a close biochemical linkage between(More)
Genome sequencing data for Streptococcus equi subspecies equi and zooepidemicus were used to develop a novel diagnostic triplex quantitative PCR (qPCR) assay targeting two genes specific to S. equi (eqbE and SEQ2190) and a unique 100 base pair control DNA sequence (SZIC) inserted into the SZO07770 pseudogene of S. zooepidemicus strain H70. This triplex(More)
(1977) "Interactions of a photoaffinity analog of GTP with the proteins of microtubules," Proc. Natl. "Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization," J. (1979) "Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as a photoaffinity label for cyclic GMP-dependent protein kinase," Proc. Natl.(More)
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