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Experiments were performed on 48 albino rats. Part of the experimental animals were initially trained to a balancing instrumental conditioned reflex (ICR). Unilateral bulbar pyramidotomy performed in all rats caused contralateral hemiparesis. On the next day following the operation 24 rats were injected intramuscularly with bacterial melanin solution. 12 of(More)
We examined the potential neuroprotective action of bacterial melanin (BM) in rats after unilateral destruction of Substantia Nigra pars compacta (SNc) dopaminergic neurons. 24 rats were initially trained to an instrumental conditioned reflex (ICR) and then subjected to unilateral electrolytic destruction of SNc. Unilateral deficit in balancing hindlimb(More)
Bacterial melanin (BM) has been used in different series of experiments as a neuroprotector. It facilitates recovery and regeneration processes after CNS lesions. The action of BM after Substantia Nigra destruction is of major interest. Electrophysiological study tries to reveal the effects of this substance on the electrical activity of Substantia Nigra(More)
Bacterial melanin has been proven to stimulate regeneration after CNS lesions. The purpose of this study was to test, whether bacterial melanin can enter the brain via the blood–brain barrier (BBB). Bacterial melanin (BM) was radioactively labeled by the iodobead method and used to test the BBB permeability after systemic injection into rats. The(More)
1 The protective role of low concentrations of water soluble bacterial melanin injected intramuscularly on the day after the unilateral ablation of the sensorimotor cortex was demonstrated in rats using the example of the recovery of operant conditioned reflexes (OCR) and movement of a paralyzed hind leg. It is known that the process of compensatory(More)
The effect of bacterial melanin (BM) solution on learning and memory impairment induced by chronic cerebral hypoperfusion in rats was studied. Male rats were injected intramuscularly with BM solution on the second day after bilateral permanent occlusion of the common carotid artery. Rats received 6 mg/ml (170 mg/kg) BM and performed significantly better in(More)
Sixteen adult male rats were initially trained to an instrumental conditioned reflex (ICR) and subjected to unilateral destruction of substantia nigra pars compacta. Part of the animals was injected with bacterial melanin solution on the next day of destruction. The other 8 rats served as the control group. Recovery rates for ICR and dynamics of paralyzed(More)
Results obtained from studies of the clinical features and course of alcohol dependence in patients with post-traumatic stress disorder (PTSD), as compared with control patients with alcohol dependence without PTSD, were studied. The first of these groups showed greater progression of illness, constant alcohol abuse, high alcohol tolerance, rapid appearance(More)
We examined post-stimulation changes in the electrical activity of neurons of the rat sensorimotor cortex after intapraperitoneal injections or direct applications of bacterial melanin (a strict analog of neuromelanin). Activation of cortical neurons was evoked by high-frequency stimulation of the hindlimb peripheral nerves. The patterns of(More)