Tiffany Tse

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Despite the importance of the immune system in many diseases, there are currently no objective benchmarks of immunological health. In an effort to identifying such markers, we used influenza vaccination in 30 young (20-30 years) and 59 older subjects (60 to >89 years) as models for strong and weak immune responses, respectively, and assayed their(More)
2 Acknowledgements I would like to take the time to thank everyone who has supported my journey at Carnegie Mellon University and this endeavor of writing a senior honors thesis. I would like to first and foremost thank my thesis advisor, Dr. Colin Clarke. Our paths crossed two summers ago when I conducted research for his book. It led me on a path to(More)
Background Immunotherapies have improved patient responses and survival , though not all patients benefit. Effective biomarkers may help to improve outcomes. Durvalumab is a human IgG1 mono-clonal antibody that inhibits PD-L1 binding to PD-1 and CD80, restoring antitumor immunity [1, 2]. PD-L1 expression on tumor or tumor-infiltrating immune cells measured(More)
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