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Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo
Activated protein C (APC) is a multifunctional serine protease with anticoagulant, cytoprotective, and anti-inflammatory activities. In addition to the cytoprotective effects of APC on endothelialExpand
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Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform.
BACKGROUND Neutrophils, the most populous innate immune cell type, are the first responders to sites of infection and inflammation. Neutrophils can release their DNA to form extracellular trapsExpand
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Determining the Bioenergetic Capacity for Fatty Acid Oxidation in the Mammalian Nervous System
The metabolic state of the brain can greatly impact neurologic function. Evidence of this includes the therapeutic benefit of a ketogenic diet in neurologic diseases, including epilepsy. However,Expand
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Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions
Abstract Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathologicalExpand
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Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin
In the contact activation pathway of the coagulation, zymogen factor XII (FXII) is converted to FXIIa, which triggers activation of FXI leading to the activation of FIX and subsequent thrombinExpand
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Abstract 592: Rapamycin Increases the Thrombogenic Potential of Neutrophil Extracellular Traps (NETs): Potential Mechanism of Prothrombotic Drug-Eluting Stents
Background: Neutrophil leukocytes are considered among the first cellular responders to bacterial host tissue infection. At sites of inflammation, neutrophils can undergo activation, releasing theirExpand