Tiffany Holmes

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Can creative visualizations of real time energy consumption patterns trigger more ecologically responsible behavior? Media art that displays the real time usage of key resources such as electricity offers new strategies to conserve energy in the home and workplace. This paper details the development of a public art project created for the National Center(More)
After peripheral nerve injury, neurotrophins play a key role in the regeneration of damaged axons that can be augmented by exercise, although the distinct roles played by neurons and Schwann cells are unclear. In this study, we evaluated the requirement for the neurotrophin, brain-derived neurotrophic factor (BDNF), in neurons and Schwann cells for the(More)
Ex vivo expansion of cord blood cells generally results in reduced stem cell activity in vivo. Glycogen synthase kinase-3beta (GSK-3beta) regulates the degradation of beta-catenin, a critical regulator of hematopoietic stem cells (HSCs). Here we show that GSK-3beta inhibition activates beta-catenin in cord blood CD34(+) cells and upregulates beta-catenin(More)
Glycogen synthase kinase-3β (GSK-3β) has been identified as an important regulator of stem cell function acting through activation of the wingless (Wnt) pathway. Here, we report that treatment with an inhibitor of GSK-3β, 6-bromoindirubin 3'-oxime (BIO) delayed cell cycle progression by increasing cell cycle time. BIO treatment resulted in the accumulation(More)
Interferon regulatory factor (IRF) 1 and its functional antagonist IRF2 were originally discovered as transcription factors that regulate the interferon-beta gene. Control of cell growth has led to the definition of IRF1 as a tumour suppressor gene and IRF2 as an oncogene. Clinically, approximately 70% of cases of acute myeloid leukaemia demonstrate(More)
INTRODUCTION Breakout, the first mass-marketable video game, was a defining game experience for many in the 1970s. It positioned Atari at the forefront of the game industry under the leadership of Apple Computer’s founders, Steve Jobs and Steve Wozniak. The long-term potency of game culture has since been firmly established. In 2001, 25 years after the(More)
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