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PURPOSE To develop and validate a fully automatic region-of-interest (ROI) delineation method for on-line adaptive radiotherapy. METHODS AND MATERIALS On-line adaptive radiotherapy requires a robust and automatic image segmentation method to delineate ROIs in on-line volumetric images. We have implemented an atlas-based image segmentation method to(More)
Tetrahedron beam computed tomography (TBCT) performs volumetric imaging using a stack of fan beams generated by a multiple pixel X-ray source. While the TBCT system was designed to overcome the scatter and detector issues faced by cone beam computed tomography (CBCT), it still suffers the same large cone angle artifacts as CBCT due to the use of approximate(More)
The purpose of this study is to describe the comprehensive commissioning process and initial clinical experience of the Mevion S250 proton therapy system, a gantry-mounted, single-room proton therapy platform clinically implemented in the S. Lee Kling Proton Therapy Center at Barnes-Jewish Hospital in St. Louis, MO, USA. The Mevion S250 system integrates a(More)
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