Tien-Shew W. Huang

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A simple means of measuring Drosophila olfactory response is described, and the behavior which it measures is characterized. The assay was used to screen for X-linked mutants defective in olfactory function. Six ota mutants were isolated and characterized (ota = olfactory trap abnormal). Four of the mutants were found to be abnormal in another chemosensory(More)
A new cell surface protein, podoendin, has been identified in Sprague-Dawley rats, and isolated using monoclonal antibody (mAb) G4. The distribution of podoendin is restricted to the surface of glomerular podocytes, urinary surface of the parietal epithelium of Bowman's capsule, and the luminal surface of endothelial cells. The antibody does not crossreact(More)
A new method for electron microscopic identification of endothelial basal lamina has been developed by treating fresh human lung tissues with 5 M guanidine HCl, pH 7.2, at 20 C for 24 hours. The guanidine treatment causes significant differential swelling and substantial decrease in electron density of the endothelial basal lamina and makes the latter(More)
Ruminal administration of 3-methylindole in goats severe pulmonary edema and respiratory distress. Electron microscopic studies of lungs reveal extensive degeneration and necrosis of alveolar membranous pneumocytes and bronchiolar epithelium. The necrosis of the pneumocytes is followed by proliferation of granular pneumocytes, which repopulate the alveolar(More)
The human glomerular basal lamina (HGBL) is composed of collagenous and noncollagenous glycoproteins. We assessed the role played by each costituent in platelet-basal-lamina interaction by selective cleavage and removal of each component by clostridial collagenase or by pepsin. When noncollagenous proteins are removed from HGBL, human platelets exhibit(More)
Dear Editor: Sweat gland carcinomas, which usually appear as papular or nodular lesions without ulceration of the skin surface (10), are rare tumors arising from eccrine or less commonly the apocrine sweat gland apparatus. As a group, sweat gland carcinomas account for approximately 0.005% of primary cutaneous tumors (11). Most tumors develop de novo in(More)
Studies of human diabetic glomerulosclerosis with a newly devleoped guanidine method have revealed that, like renal tubules, thickening of the glomerular capillary basal lamina is due exclusively to inordinate accumulation of the epithelial basal lamina. There is no excessive deposition of the endothelial basal lamina. Thus, the diabetic nephropathy is(More)