Tieh-Ching Chang

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BACKGROUND A tri-allelic serotonin transporter promoter polymorphism (5-HTTLPR/rs25531) more effectively determines the levels of transcriptional efficacy than that with the bi-allelic 5-HTTLPR polymorphism in vitro. Both are reportedly associated with personality traits of negative emotionality, but with conflicting findings. One explanation for this is(More)
Neuropeptide Y (NPY) is involved in resilience to stress, and higher vagal (parasympathetic) activity has been associated with greater stress resilience. Thus, we examined whether rs16147, a functional promoter polymorphism (C>T) of the NPY gene, could influence vagal tone during chronic high stress levels. NPY genotyping, chronic psychological stress level(More)
Decreased resting vagal (parasympathetic) tone is implicated in the development of stress-related disorders, including anxiety and depression. Chronic stress elevates the expression of serotonin 2A receptors (5-HT2A), while activation of 5-HT2A leads to inhibition of parasympathetic synaptic transmission. The T allele of the promoter variant, rs6311 (C>T),(More)
A previous retrospective study reported that antidepressant treatment with escitalopram, a selective serotonin re-uptake inhibitor (SSRI), significantly reduced the platelet count, whereas bupropion, a noradrenalin and dopamine re-uptake inhibitor (NDRI) had no such effect (Song et al., 2012). Whether escitalopram-related thrombocytopenia can be reversed(More)
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