Tie-jian Jiang

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The present study evaluated the effects of KCNQ1 rs2237892 and rs2237895 polymorphisms on repaglinide efficacy in Chinese patients with type 2 diabetes mellitus (T2DM). In all, 367 T2DM patients and 214 controls were genotyped. Forty of the T2DM patients were randomly selected to undergo 8 weeks repaglinide treatment. The frequency of the rs2237892 allele(More)
MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells(More)
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β superfamily. Recent studies confirmed that GDF11 plays an important role in regulating the regeneration of brain, skeletal muscle, and heart during aging; however, its role in bone metabolism remains unclear. Thus, the aim of this study was to determine the effects of(More)
MicroRNAs (miRNAs) involve in the regulation of a wide range of physiological processes. Recent studies suggested that miRNAs might play a role in osteoclast differentiation. Here, we identify a new miRNA (miR-9718) in primary mouse osteoclasts that promotes osteoclast differentiation by repressing protein inhibitor of activated STAT3 (PIAS3) at the(More)
BACKGROUND Omentin-1, as a newly discovered adipocytokine, plays an important role in bone metabolism. However, the association between circulating omentin-1 level and bone mineral density (BMD) in Chinese women has never been investigated. METHODS Serum omentin-1, adiponectin, leptin, bone turnover biochemical markers, BMD were determined in 225(More)
OBJECTIVE To investigate the effects of subcutaneous administration of insulin on insulitis,beta cell apoptosis and diabetes in non-obese diabetic (NOD) mice, and to explore the mechanism of immune tolerance induced by insulin. METHODS Sixty female NOD mice were randomly divided into insulin group (n=32) and phosphate buffered saline (PBS) group (PBS(More)
OBJECTIVE To investigate the effect of oral administration of insulin on insulitis beta cell apoptosis and diabetes in non-obese diabetic (NOD) mice, and to explore the mechanism of immune tolerance induced by insulin. METHODS Eighty-six female NOD mice were randomly divided into an insulin group (n=43) and a phosphate buffered saline (PBS) group (n=43).(More)
OBJECTIVE To investigate the method of isolating and purifying islets in non-obese diabetic (NOD) mice. METHODS The isolation of adult NOD mice pancreatic islets was carried out by stationary digestion after pancreatic ductal injection of collagenase solution. A discontinuous Ficoll solution (25%, 23%, 20.5%, 11%) was applied to the purification of the(More)
OBJECTIVE To explore the effects of pioglitazone on insulitis and diabetes and relevant mechanism. METHODS Seventy-three female non-obese diabetic (NOD)/Lt mice aged 4 weeks were randomly divided into 3 groups, control group (n = 25, fed with regular diet), low dosage pioglitazone group (n = 23, pioglitazone of the concentration of 0.01% was added into(More)
OBJECTIVE To explore the effects of complete Freund's adjuvant (CFA), incomplete Freund's adjuvant(IFA), large multilamellar liposome (LML) and small cationic liposome (DOTAP) on insulitis and diabetes. METHODS 1. 3-week-old non-obese diabetic(NOD) female mice were randomly divided into 3 groups: CFA group (injected subcutaneously in the hind footpad, n =(More)