Feedforward activation processes are widely regarded as crucial for the automatic initiation of motor responses, whereas recurrent processes are often regarded as crucial for visual awareness. Here, we used a set of behavioral criteria to evaluate whether rapid processing in the human visuomotor system proceeds as would be expected of a feedforward system… (More)
Autosomal dominant spinocerebellar ataxias (SCA) form a group of clinically and genetically heterogeneous neurodegenerative disorders. The defect responsible for SCA3/Machado-Joseph disease (MJD) has been identified as an unstable and expanded (CAG)n trinucleotide repeat in the coding region of a novel gene of unknown function. The MJD1 gene product,… (More)
—Feedforward activation processes are widely regarded as crucial for the automatic initiation of motor responses , whereas recurrent processes are often regarded as crucial for visual awareness. Here, we used a set of behav-ioral criteria to evaluate whether rapid processing in the visuomotor system proceeds as would be expected of a feed-forward system… (More)
The genetic basis of neurodegeneration in Huntington's disease (HD) has been identified as a (CAG)(>37) repeat expansion in a gene of unknown function. Interestingly, patients with the same expanded (CAG)(n) repeat length may have markedly different ages at onset. Based on experiences in animal models the level of expression might be one of the modifying… (More)
Abelson interactor protein 1 (Abi-1) localizes to postsynaptic densities (PSDs) of excitatory synapses and was shown to be transported from the PSD to the nucleus and back depending upon synaptic activation. We employed a yeast-two-hybrid screen to search for putative transport molecules. We found Kif26B a member of the Kif family of transport proteins that… (More)
2016 Highly efficient mouse genome editing by CRISPR ribonucleoprotein electroporation of zygotes. Chemical control of grafted human PSC-derived neurons in a mouse model of Parkinson's disease. Combinatorial metabolic pathway assembly in the yeast genome with RNA-guided Cas9. Human monocytes engage an alternative inflammasome pathway. Activation of RNase L… (More)
Analysis of high salt washed ribosomal proteins by two-dimensional polyacrylamide electrophoresis revealed no detectable qualitative differences in ribosomal proteins from young (4-day) and old (30-day) male flies.