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Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role. This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Sprague-Dawley rats were trained in a Y-maze until they(More)
Accumulating evidence shows the disruption of hippocampal neurotrophins secretion leads to memory deficits in Alzheimer's disease (AD) animal models. Invasive injection of exogenous neurotrophins into hippocampus reverses spatial memory deficits, but its clinical application is limited by traumatic brain injury during the injection procedure. Notably,(More)
Cross-frequency coupling (CFC) between the theta (4-12Hz) phase and the amplitude of gamma (30-100Hz) oscillations occurs frequently in brain. However, the function of theta-gamma coupling in rat medial prefrontal cortex (mPFC) in working memory remains unclear. To address this issue, we studied 16-channel CFC in local field potentials (LFPs) recorded from(More)
Working memory (WM) refers to the short-term maintenance of information with higher cognitive functions. Recent researches show that local field potentials (LFPs) and spikes, as different modes of neural signals, encode WM, respectively. There is a growing interest in how these two signals encode WM in coordination. The aim of this study is to investigate(More)
Working memory (WM) is necessary in higher cognition. The brain as a complex network is formed by interconnections among neurons. Connectivity results in neural dynamics to support cognition. The first aim is to investigate connectivity dynamics in medial prefrontal cortex (mPFC) networks during WM. As brain neural activity is sparse, the second aim is to(More)
Repetitive transcranial magnetic stimulation (rTMS) is able to induce alteration in cortical activity and excitability that outlast the period of stimulation, which is long-term depre-ssion (LTD) or long-term potentiation (LTP)-like. Accumulating evidence shows that Na(+), Ca(2+) and K(+) channels are important for the regulation of neuronal excitability.(More)
Alzheimer's disease (AD) is a neurodegenerative disease that gradually induces cognitive deficits in the elderly. Impairment of working memory was typically observed in AD. As amyloid-β peptide (Aβ) is a causative factor for the cognitive impairments in AD, developing a mechanistic understanding of the contribution of Aβ to cognitive impairments may yield(More)
Ion-exchange fiber undergoes a stoichiometric exchange reaction and has large exchange capability, which makes it a promising candidate as a multiple drug carrier. Because combinatorial effects can act synergistically, additively or antagonistically depending on the ratio of the agents being combined, the objective of this study was to learn the dual drug(More)
Working memory refers to a brain system that provides temporary storage to manipulate information for complex cognitive tasks. As the brain is a more complex, dynamic and interwoven network of connections and interactions, the questions raised here: how to investigate the mechanism of working memory from the view of functional connectivity in brain network?(More)
Alzheimer's disease (AD) is a neurodegenerative disease that gradually induces cognitive deficits. Impairments of working memory have been typically observed in AD. It is well known that spikes and local field potentials (LFPs) as well as the coordination between them encode information in normal brain function. However, the abnormal coordination between(More)