Tianyu Zhang

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Driving the cochlea in reverse via the round window membrane (RWM) is an alternative treatment option for the hearing rehabilitation of a nonfunctional or malformed middle ear. However, cochlear stimulation from the RWM side is not a normal sound transmission pathway. The basilar membrane (BM) motion elicited by mechanical stimulation of the RWM is unknown.(More)
OBJECTIVE To describe a modified meatoplasty for external auditory canal stenosis with endoaural-conchal incision. STUDY DESIGN Retrospective clinical study. SETTING Tertiary referral hospital. PATIENTS There were 140 patients (145 ears) who had undergone surgical correction for external auditory canal stenosis from 2003 to 2010. INTERVENTION The(More)
PURPOSE This retrospective study determined the delayed-type hypersensitivity (DTH) skin test and safety of dendritic cell (DC) vaccine and cytokine-induced killer (CIK) cell immunotherapy and the survival compared to chemotherapy in 239 colorectal cancer (CRC) patients. METHODS DTH and safety of the immunotherapy were recorded. The overall survival (OS)(More)
PURPOSE To determine the immune response after dendritic cell (DC) vaccine and cytokine-induced killer cells (CIK) therapy and assess its associated toxicity, survival benefit, and changes in the quality of life (QOL) of advanced colorectal cancer (CRC) patients. METHODS We recruited 100 patients with unresectable CRC orrelapsed CRC after surgery who(More)
Neddylation, a newly identified post-translational modification, is significant for the activity and stability of target proteins. The exact role of neddylation in the pathogenesis of inflammatory bowel disease, specifically those mediated by dendritic cells (DCs), was still rarely reported. Here, we showed that inhibition of neddylation protected mice from(More)
Objective. To evaluate the efficacy of infliximab (IFX) monotherapy versus infliximab-azathioprine sequential treatment in Crohn's disease (CD) patients. Methods. Patients newly diagnosed with CD using IFX as induction therapy were enrolled. After 6 times of IFX infusions, they were divided into IFX monotherapy group and IFX-AZA sequential therapy group.(More)
OBJECTIVES The aims of this article are: 1) to re-evaluate the accuracy of multiple planar reconstruction computed tomography (MPR-CT) imaging on stapes-prosthesis parameters, and 2) to clarify possible relationships between prosthesis intravestibular depth and postoperative hearing outcomes. PATIENTS Seventy patients (46 women and 24 men; 32 right and 38(More)
BACKGROUND Disease severity, illness perceptions, coping strategies, stress, psychological well-being, and quality of life were reported to have close relationships. According to the Common Sense Model, illness perceptions and coping strategies could mediate the relationship between illness stimuli and illness outcomes such as psychological health and(More)
OBJECTIVE To test whether there are significant differences in the morphologic features of the enlarged vestibular aqueduct (EVA) and its anatomic relationships with adjacent structures between EVA patients with and without other inner ear malformations. METHODS The morphology of vestibular aqueduct, volume of vestibule, and anatomic location of facial(More)
In order to investigate the location of the mastoid portion of the facial nerve in patients with congenital aural atresia and to assess its effect on the round window middle ear implant (MEI) transducer implantation approach, 70 patients with unilateral congenital aural atresia were examined by computer tomography (CT). The patients were divided into two(More)