Tianyu Zhang

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Human Golgi phosphoprotein 2 gene (also known as GOLPH2, GP73 or GOLM1) encodes an epithelial-specific Golgi membrane protein which can be induced by virus infection. It is also overexpressed in a number of tumors and is currently considered as an early diagnosis marker for hepatocellular carcinoma. However, little is known about how GOLPH2 is dysregulated(More)
AIMS Sildenafil, a phosphodiesterase type 5 inhibitor, has been found to produce functional recovery in ischemic rats by increasing the cGMP level and triggering neurogenesis. The aim of this study was to investigate further sildenafil mechanisms. METHODS Male Sprague-Dawley rats underwent middle cerebral artery occlusion and reperfusion, followed by(More)
PURPOSE To determine the immune response after dendritic cell (DC) vaccine and cytokine-induced killer cells (CIK) therapy and assess its associated toxicity, survival benefit, and changes in the quality of life (QOL) of advanced colorectal cancer (CRC) patients. METHODS We recruited 100 patients with unresectable CRC orrelapsed CRC after surgery who(More)
The purpose of this study was to determine the quantitative relationships between the positions of the sigmoid sinus (SS) and jugular bulb (JB) and the influence of mastoid pneumatization upon these structures. The investigations were carried out on 116 healthy adult ears based on the axial images of computed tomography (CT). The reference system locating(More)
PURPOSE This retrospective study determined the delayed-type hypersensitivity (DTH) skin test and safety of dendritic cell (DC) vaccine and cytokine-induced killer (CIK) cell immunotherapy and the survival compared to chemotherapy in 239 colorectal cancer (CRC) patients. METHODS DTH and safety of the immunotherapy were recorded. The overall survival (OS)(More)
BACKGROUND The aim of the study was to evaluate clinical manifestations, T-SPOT, endoscopy and CT enterography to differentiate Crohn's disease (CD) from intestinal tuberculosis (ITB). METHODS 128 in patients with suspected CD and ITB were prospectively enrolled in the study. Demographic, clinical, laboratory, endoscopic and CT enterographic data were(More)
HYPOTHESIS To delineate quantitatively the spatial relationships of the utricle, saccule, and stapedial footplate, to locate the hole on the footplate, and to analyze the insertion depth into the vestibule and the direction of the piston during stapedotomy. BACKGROUND The quantitative three-dimensional (3D) configuration of the utricle, saccule, and(More)
OBJECTIVE To evaluate the effect of intratympanic dexamethasone (ITD) as initial therapy for idiopathic sudden sensorineural hearing loss (ISSHL) as well as to determine the concentration-dependent time course distribution of dexamethasone in the inner ear. METHODS Sixty-six patients with profound ISSHL were included. Twenty-two were treated with ITD and(More)
and Applied Analysis 3 Theorem 1.6 5 , Theorem 4 . Letf : I → R0 be differentiable on I◦, a, b ∈ I, a < b, and f ′ ∈ L a, b . If |f ′ x | is s-convex on a, b for some s ∈ 0, 1 , and p, q ≥ 1, such that 1/q 1/p 1 then ∣ ∣ ∣ ∣ ∣ f ( a b 2 ) − 1 b − a ∫b a f x dx ∣ ∣ ∣ ∣ ∣ ≤ 2−1/p ∣f ′ a ∣ ∣q s 1 ∣ ∣f ′ a b /2 ∣ ∣q)1/q { s 1 s 2 } 2−1/p ∣f ′ b ∣ ∣q s 1 ∣ ∣f ′(More)
Although genetically modified (GM) plants have improved commercially important traits, such as biomass and biofuel production, digestibility, bioremediation, ornamental value, and tolerance to biotic and abiotic stresses, there remain economic, political, or social concerns over potential ecological effects of transgene flow from GM plants. The current(More)