- Full text PDF available (3)
Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress, measured by increased NF-κB activity, induces LOI in both… (More)
A series of nitrogen-containing apigenin analogs 4a–j was synthesized via Mannich reactions to develop anticancer, antibacterial, and antioxidant agents from plant-derived flavonoids. The chemical structures of these compounds were confirmed using 1 H-NMR, 13 C-NMR, and ESI-MS. The in vitro biological activities of the analogs were evaluated via assays of… (More)
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.