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Ghrelin, a 28-amino acid peptide, is mainly secreted by the stomach. Ghrelin has been shown to have neuroprotective effects. However, whether ghrelin protects the spinal cord from ischemia/reperfusion (I/R) injury is unknown. To investigate this, 60 rats were randomly divided into three different groups: the sham group (n = 20), the vehicle group (n = 20),(More)
OBJECT The authors undertook a study in patients with traumatic central cord syndrome (TCCS) who underwent surgical intervention. They retrospectively assessed the motor score improvement and functional status and identified prognostic predictors of improvement. METHODS Between March 1999 and May 2004, 49 patients with TCCS were surgically treated. Motor(More)
Spinal cord injury (SCI) results in the loss of function below the lesion. Secondary injury following the primary impact includes a number of biochemical and cellular alterations leading to tissue necrosis and cell death. Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor of nuclear hormone receptor superfamily.(More)
OBJECT The nucleus pulposus has been reported to be an immunologically privileged site. The expression of Fas ligand (FasL) on normal and herniated lumbar disc cells has been reported. The relationship between a physiological barrier and the role of FasL has not yet been addressed. To clarify this relationship and to investigate a possible pathogenesis of(More)
OBJECTIVE To compare the neuroprotective effects of methylprednisolone (MPSS) and rosiglitazone (ROSG) following spinal cord injury (SCI). METHODS This study was carried out at the Institute of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou, China between June 2009 and March 2010. One hundred and twenty Sprague-Dawley rats after(More)
Nineteen patients with post-traumatic osteoporotic vertebral osteonecrosis were treated using percutaneous balloon kyphoplasty. The anterior and middle vertebral heights, as well as the kyphotic angle, were measured using a standing lateral radiograph before surgery, 2 days after surgery and at the final follow-up. At the same time points, a visual analog(More)
The purpose of this study was to determine the entry point and the depth of a guide needle in a transpedicular procedure of the lower thoracic and lumbar spine on standard fluoroscopic views. Ten human cadaveric thoracolumbar spines (T9-L5) were anatomized into single vertebrae. The transpedicular puncturing needle was inserted and placed under the anterior(More)
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