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LncRNA LINC00963 Promotes Tumorigenesis and Radioresistance in Breast Cancer by Sponging miR-324-3p and Inducing ACK1 Expression
LINC00963 promotes tumorigenesis and radioresistance in breast cancer through interplay with miR-324-3p and derepression of ACK1 and may represent a potential target for the treatment of breast cancer. Expand
Identification of YTH Domain-Containing Proteins as the Readers for N1-Methyladenosine in RNA.
This work identified multiple putative protein readers of m1A in RNA, including several YTH domain family proteins, and found that Trp432 in YTHDF2, a conserved residue in the hydrophobic pocket of the YTHdomain that is necessary for its binding to N6-methyladenosine (m6A), is required for its recognition ofm1A. Expand
Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution.
This work introduced the atom-specific replacement of oxygen with progressively larger atoms (sulfur and selenium) at 4-position of deoxythymidine triphosphate to weaken its ability to base pair with m6A, while maintaining A-T* base pair virtually the same as the natural one. Expand
Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein.
It is identified that fluorescein derivatives can selectively inhibit FTO demethylation and these inhibitors can also be applied to the direct labeling and enrichment of FTO protein combined with photoaffinity labeling assay. Expand
Geniposide Attenuates Post-Ischaemic Neurovascular Damage via GluN2A/AKT/ ERK-Dependent Mechanism
The results suggest that geniposide protects neurons against post-ischaemic neurovascular injury through the activation of GluN2A/AKT/ERK pathways and may be a future therapeutic for stroke patients. Expand
Selective detection of N6-methyladenine in DNA via metal ion-mediated replication and rolling circle amplification† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02271e
6mA can be discriminated from A in DNA due to the remarkable difference in stability between A–Ag+–C and 6mA–Ag+–C.
Fluorescent strategy based on cationic conjugated polymer fluorescence resonance energy transfer for the quantification of 5-(hydroxymethyl)cytosine in genomic DNA.
A new method for 5-hmC quantification in genomic DNA based on CCP-FRET (cationic conjugated polymers act as the energy donor and induce fluorescence resonance energy transfer) assay combined with KRuO4 oxidation is reported. Expand
Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug.
Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potentialExpand
Application of N-halogeno-N-sodiobenzenesulfonamide reagents to the selective detection of 5-methylcytosine in DNA sequences.
Two N-halogeno-N-sodiobenzenesulfonamide reagents are designed and synthesized that provide a new chemical method for probing (5Me)dC in DNA sequences and distinguished from 5-hydroxymethyl-2'-deoxycytidine and deoxycyTidine through the introduction of a glucose moiety to the hydroxyl group of (5hm)dD. Expand
A mitochondria-targeted zinc(II) phthalocyanine for photodynamic therapy
A water-soluble zinc(II) phthalocyanine (ZnPc1) substituted with 1-(3-methyl) imidazoliumylethyloxy on the periphery was synthesized, and its subcellular localization and photodynamic activities wereExpand