Tianhe Sun

Ursula Storb2
Silvia M. Vidal1
2Ursula Storb
1Silvia M. Vidal
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Natural killer (NK) cells are crucial in resistance to certain viral infections, but the mechanisms used to recognize infected cells remain largely unknown. Here, we show that the activating Ly49P receptor recognizes cells infected with mouse cytomegalovirus (MCMV) by a process that requires the presence of H2-D(k) and the MCMV m04 protein. Using H2(More)
Gene-targeted mice were generated with a loxP-neomycin resistance gene (neo r) cassette inserted upstream of the J ␭ 1 region and replacement of the glycine 154 codon in the C ␭ 1 gene with a serine codon. This insertion dramatically increases V ␭ 1-J ␭ 1 recombination. J ␭ 1 germ-line transcription levels in pre-B cells and thymus cells are also greatly(More)
This study is an investigation of the possible role of DNA polymerase (pol) delta with an inactivated exonuclease (exo) in somatic hypermutation (SHM). Analysis of endogenous heavy chain transcripts revealed no difference in mutation frequency and pattern between exo(-/-), exo(+/-) and exo(+/+) mice. The lack of an effect of the pol delta exo mutation on(More)
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