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FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis
Qian et al. show that the receptor tyrosine kinase FLT1 is highly expressed in a subset of macrophages enriched in breast cancer metastatic sites. Inhibition of this kinase reduces metastasis to theExpand
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DNA Polymerase ɛ Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity
Two cases of metastatic colorectal cancer with a POLE mutation, both of which were ultramutated and microsatellite stable, are presented and discussed from the standpoint of the basic biochemicalExpand
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MET/HGF pathway activation as a paradigm of resistance to targeted therapies.
Resistance to targeted therapeutics is a key issue limiting the long-term utility of these medications in the management of molecularly selected subsets of cancer patients, including patients withExpand
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Update of systemic immunotherapy for advanced urothelial carcinoma.
PURPOSE Until recently, therapeutic options for metastatic urothelial carcinoma (UC) were limited to cytotoxic chemotherapy. Cisplatin-based combination chemotherapy has proven benefit in theExpand
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Emerging drugs for urothelial (bladder) cancer
ABSTRACT Introduction: Metastatic urothelial carcinoma has been associated with poor prognosis and a median survival of approximately 12–14 months with standard therapy. Treatment options for decadesExpand
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