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The presence and quantity of rare cells in the bloodstream of cancer patients provide a potentially accessible source for the early detection of invasive cancer and for monitoring the treatment of advanced diseases. The separation of rare cells from peripheral blood, as a "virtual and real-time liquid biopsy", is expected to replace conventional tissue(More)
By a simple and convenient method of using formaldehyde as linkages, two new chitosan (CS) derivatives modified respectively with thiosemicarbazide (TSFCS) and thiocarbohydrazide (TCFCS) were synthesized. The new compounds were characterized and studied by Fourier transform infrared spectroscopy, elemental analysis, thermal gravity analysis and differential(More)
Studies on the degeneration and regeneration of neurons as individual compartments of axons or somata can provide critical information for the clinical therapy of nervous system diseases. A controllable in vitro platform for multiple purposes is key to such studies. In the present study, we describe an integrated microfluidic device designed for achieving(More)
The construction of a micro-platform capable of microscale control for continuous, dynamic, and high-throughput biomimetic tumor manipulation and analysis plays a significant role in biological and clinical research. Here, we introduce a pneumatic microstructure-based microfluidic platform for versatile three-dimensional (3D) tumor cultures. The(More)
A novel, facile, and flexible approach for the easy assembly of microfluidic droplet devices using commercially available components is presented. Three different types of devices have been designed and tested, and the experimental results indicated that the devices offer a promising platform for the controllable generation of highly monodisperse droplets(More)
The development and application of miniaturized platforms with the capability for microscale and dynamic control of biomimetic and high-throughput three-dimensional (3D) culture plays a crucial role in biological research. In this study, pneumatic microstructure-based microfluidics was used to systematically demonstrate 3D tumor culture under various(More)
Controllable manipulation of fluid flow is crucial for efficient particle separation, which is associated with plenty of biomedical and industrial applications. Microfluidic technologies have achieved promising progress in particle positioning depending on inertial force with or without the help of the Dean effect. Herein, we describe an inertial(More)
β-BiNbO4 with a high temperature triclinic form was prepared via a high-temperature solid-state reaction ceramic method. Structural refinement and surface characteristic studies were performed. The optical absorption, and electronic calculation of the band structures and density of states were also studied. β-BiNbO4 ceramic has an indirect transition with a(More)
Redox-active hollow spheres were prepared through extracting a polystyrene core from the latex particle (PSPAAFc) composed of the core and the polyallylamine shell including ferrocenyl carboxylic amide. The suspension of the hollow spheres showed anodic and cathodic voltammetric peaks, which were nearly reversible and diffusion-controlled. The current was 3(More)
An Au nanoparticles/poly(caffeic acid) (AuNPs/PCA) composite modified glassy carbon (GC) electrode was prepared by successively potentiostatic technique in pH 7.4 phosphate buffer solution containing 0.02mM caffeic acid and 1.0mM HAuCl4. Electrochemical characterization of the AuNPs/PCA-GC electrode was investigated by electrochemical impedance spectroscopy(More)