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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy.
The engineered c(RGDyK)-conjugated exosomes (cRGD-Exo) target the lesion region of the ischemic brain after intravenous administration and provide a strategy for the rapid and large-scale production of functionalized exosome. Expand
Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction
A new mechanism by which Hypo-Exo-derived miR125b-5p facilitates ischemic cardiac repair by ameliorating cardiomyocyte apoptosis is illustrated, and the IMT- Exo may serve as a novel drug carrier that enhances the specificity of drug delivery for isChemic disease. Expand
Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice
In a transient middle cerebral artery occlusion mouse model, the RGD-exo:miR-210 targets the lesion region of the ischemic brain after intravenous administration, resulting in an increase in miR- 210 at the site. Expand
Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription.
The mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation and upregulation of glycolysis and uncovered a novel mechanism by which mitomiRNA regulates mitochondrial transcription. Expand
Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy.
This study combines radiation therapy to prime the tumor for nanoparticle uptake along with the targeting effect of iRGD-conjugated nanoparticles to yield a straightforward but effective approach for combined EGFR inhibition and immunotherapy against glioblastomas, which can be extended to other aggressive tumor types. Expand
Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing
A model in which lncRNAs impair microprocessor recognition and are efficient of pre-miRNA cropping is proposed and provided for the first time the rationale for lncRNA and miRNA biogenesis for predicting chemosensitivity and patient clinical prognosis is proposed. Expand
Differential Expression of Proteins Associated with the Hair Follicle Cycle - Proteomics and Bioinformatics Analyses
The above data may provide insight into the three stages of mouse hair follicle morphogenesis and provide a solid basis for potential therapeutic molecular targets for this hair disease. Expand
lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter
The potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity is uncovered and a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites is proposed. Expand
Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF‐κB/STAT3 Signaling
It is shown that EVs derived from MES cells educate PN cells to increase stemness, invasiveness, cell proliferation, migration potential, aggressiveness, and therapeutic resistance by inducing mesenchymal transition through nuclear factor‐κB/signal transducer and activator of transcription 3 signaling. Expand
CAR (CARSKNKDC) Peptide Modified ReNcell-Derived Extracellular Vesicles as a Novel Therapeutic Agent for Targeted Pulmonary Hypertension Therapy
The results provide an alternative to MSCs-derived EVs–based PH therapy via using ReNcell as a reliable source of EVs and CAR-conjugated EVs may serve as a novel drug carrier that enhances the specificity and efficiency of drug delivery for effective PH-targeted therapy. Expand