Learn More
This paper describes the design, implementation and evaluation of a wearable interface for ubiquitous gaming, dubbed Gauntlet. Our objective has been to achieve a user interface for intuitive and immersive interaction in mobile gaming environments, but generic enough to be used in diverse game styles and untethered from location-specific hardware and(More)
This paper focuses on the design and development of an authoring environment for the InStory project. InStory is a platform for mobile storytelling, gaming activities and information access. It focuses on the exploration of cultural and historical physical spaces, promoting interaction between users. During those explorations, users have access to(More)
In this paper we present a wearable user interface for ubiquitous gaming activities, discussing the design choices that led to the implementation of a first, fully functional prototype. The Gauntlet takes the form of an unobtrusive arm piece that allows gestures and manipulation of real objects to be included as game-play elements. When paired to a mobile(More)
Diabetic retinopathy is a leading cause of vision loss and blindness. Disruption of axonal transport is associated with many neurodegenerative diseases and might also play a role in diabetes-associated disorders affecting nervous system. We investigated the impact of type 1 diabetes (2 and 8 weeks duration) on KIF1A, KIF5B and dynein motor proteins in the(More)
An evolutionary generative system for type design, Evotype, is described. The system uses a Genetic Algorithm to evolve a set of individuals composed of line segments, each encoding the shape of a specific character, i.e. a glyph. To simultaneously evolve glyphs for the entire alphabet, an island model is adopted. To assign fitness we resort to a scheme(More)
The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study hypothesized that STC1 may be implicated in the regulation of gluconeogenesis in the vertebrate kidney. Human STC1(More)
Death of retinal neural cells, namely retinal ganglion cells (RGCs), is a characteristic of several retinal neurodegenerative diseases. Although the role of adenosine A3 receptor (A3R) in neuroprotection is controversial, A3R activation has been reported to afford protection against several brain insults, with few studies in the retina. In vitro models(More)
Glaucoma is a leading cause of vision loss and blindness worldwide, characterized by chronic and progressive neuronal loss. Reactive microglial cells have been recognized as a neuropathologic feature, contributing to local inflammation and retinal neurodegeneration. In a recent in vitro work (organotypic cultures), we demonstrated that blockade of adenosine(More)