Tiago Amado

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Cilia and flagella are involved in a variety of processes and human diseases, including ciliopathies and sterility. Their motility is often controlled by a central microtubule (MT) pair localized within the ciliary MT-based skeleton, the axoneme. We characterized the formation of the motility apparatus in detail in Drosophila spermatogenesis. We show that(More)
Polo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole amplification. The SCF-Slimb/βTrCP-E3 ubiquitin ligase controls PLK4 levels through recognition of a conserved phosphodegron. SCF-Slimb/βTrCP substrate binding and targeting for degradation is normally regulated by(More)
Figure S1, related to Figure 1 Complete serial cross section image set of the representative images shown in Figure 1. Longitudinal tomogram stills and corresponding schematic model of a primary spermatocyte basal body/cilium, complementing the data shown in Figure 1. Complete serial cross section image set of the representative images shown in Figure 2.(More)
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