Tia S Douglass

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Dopamine inhibited phosphate transport in isolated renal brush border membrane vesicles and in cultured renal proximal tubule cells from wild-type but not from NHERF-1 null mice. Co-immunoprecipitation experiments established that NHERF-1 associated with D1-like receptors. In wild-type mice, dopamine stimulated cAMP accumulation and protein kinase C (PKC)(More)
To follow up on a previous finding of an elevated colorectal cancer incidence rate among Exxon employees on a unit devoted to the manufacture of polypropylene (the polyolefin unit [POU]), a company-sponsored screening program was offered to all former and present POU workers. Overall participation was 52.5%, with lower participation among older workers and(More)
In response to reports of an unusually high number of colorectal cancers among employees on a unit devoted to the manufacture of polypropylene, we examined colorectal cancer incidence rates for 335 workers with at least 6 months employment on this unit from 1960 to 1985. Assuming a 10-year latent period, we found a significant 5.6-fold colorectal cancer(More)
In order to study the biosynthesis, composition, and origin of sterols in the Florida land crabs, Cardisoma guanhumi (Latreille), we fed 17 male crabs either a cholesterol-free or a high cholesterol diet for 2 to 7 weeks. The origin of sterols in these crabs, whether from biosynthesis or from the diet, was determined by tahree procedures: the incorporation(More)
This study reports factors associated with participation in a colorectal cancer screening program for a cohort of workers on a polypropylene manufacturing unit. The impetus for the screening program was the discovery of a colorectal cancer cluster among workers on this unit. The program included a life-style/risk factor questionnaire, fecal occult blood(More)
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