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Licofelone Enhances the Efficacy of Paclitaxel in Ovarian Cancer by Reversing Drug Resistance and Tumor Stem-like Properties.
Drug development for first-line treatment of epithelial ovarian cancer (EOC) has been stagnant for almost three decades. Traditional cell culture methods for primary drug screening do not always… Expand
KISS1 in metastatic cancer research and treatment: potential and paradoxes
The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm… Expand
Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1
- Sitaram Harihar, Srijit Ray, Samyukta Narayanan, A. Santhoshkumar, Thuc Ly, D. Welch
- Clinical & Experimental Metastasis
- 22 February 2020
KISS1 , a metastasis suppressor gene, has been shown to block metastasis without affecting primary tumor formation. Loss of KISS1 leads to invasion and metastasis in multiple cancers, which is the… Expand