Thriyambakam Krishnan

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In this paper we discuss the problem of signal reconstruction from spectral magnitude or phase using group delay functions. We define two separate group delay functions for a signal, one is derived from the magnitude and the other from the phase of the Fourier transform of the signal. The group delay functions offer insight into the problem of signal(More)
Melittin is the major active ingredient in bee venom and has been widely studied for its membrane-fusion property. We have explored the possibility of determining a concentration range of melittin where it is relatively safe to be used as an adsorption enhancer. Melittin's potential use as an adsorption enhancer for mannitol was determined using Caco-2(More)
Topical delivery of cyclosporin A (CSA) is desirable for treating psoriasis, but it is hindered by the barrier property of stratum corneum, and the physicochemical properties of CSA. Attempts to deliver CSA from a solution prepared in 40% ethanol (EtOH) is phosphate buffered saline (PBS) using iontophoresis did not result in any significant increase in drug(More)
Drug delivery particulates were prepared using alginate, polylysine and pectin. Theophylline, chlorothiazide and indomethacin were used as the model drugs for in-vitro assessments, and mannitol was the model for assessing paracellular drug absorption across Caco-2 cell monolayers. Alginate and pectin served as the core polymers and polylysine helped to(More)
This article reviews the literature on solid-phase extraction published in the last 10 years. Emphasis has been placed on dealing with samples of biological origin. The sections consist of introduction, history and development, types of columns, selection of a suitable column, types of samples, advantages and applications.
The use of electroporation pulses as a physical means of enhancing the permeability of skin to deliver drugs is in the early stages of development. In this article, a systematic study examining the parameters influencing electroporative transdermal delivery of terazosin hydrochloride to hairless rat skin are reported. It was found that voltage, pulse length(More)
A previous study indicated that the parameters governing the performance of electroporative delivery to the skin, are voltage, pulse length, number of pulses and electrode area.1 This article describes a study in which the reversibility of the electroporation technique is evaluated with in vitro methods. The skin's reversal from an enhanced permeation mode(More)