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A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
Midbrain neurons synthesizing the neurotransmitter dopamine play a central role in the modulation of different brain functions and are associated with major neurological and psychiatric disorders.Expand
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Neuroprotection from Stroke in the Absence of MHCI or PirB
Recovery from stroke engages mechanisms of neural plasticity. Here we examine a role for MHC class I (MHCI) H2-Kb and H2-Db, as well as PirB receptor. These molecules restrict synaptic plasticity andExpand
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Fibroblast Growth Factor Receptors Cooperate to Regulate Neural Progenitor Properties in the Developing Midbrain and Hindbrain
Fibroblast growth factors (FGFs) secreted from the midbrain–rhombomere 1 (r1) boundary instruct cell behavior in the surrounding neuroectoderm. For example, a combination of FGF and sonic hedgehogExpand
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Expression of Fgf receptors 1, 2, and 3 in the developing mid‐ and hindbrain of the mouse
Fibroblast growth factor 8 (FGF8) mediates the function of the midbrain–hindbrain organizer (MHO). FGF signals are transmitted by means of four known FGF receptors (FGFRs). Studies of Fgfr expressionExpand
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Fgfr1-dependent boundary cells between developing mid- and hindbrain.
Signaling molecules regulating development of the midbrain and anterior hindbrain are expressed in distinct bands of cells around the midbrain-hindbrain boundary. Very little is known about theExpand
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FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region.
The neuroectodermal tissue close to the midbrain-hindbrain boundary (MHB) is an important secondary organizer in the developing neural tube. This so-called isthmic organizer (IsO) secretes signalingExpand
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Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain.
The mid-/hindbrain organizer (MHO) is characterized by the expression of a network of genes, which controls the patterning and development of the prospective midbrain and anterior hindbrain. One keyExpand
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Specific and redundant functions of Fgf receptors in development of the midbrain and anterior hindbrain of the mouse
Fibroblast growth factors (Fgfs) are important for the development of the mid-/hindbrain region (MHR). The inactivation of Fgf8 in the MHR leads to a complete loss of tissue in that region. AExpand