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L-type calcium currents were studied in ventricular myocytes isolated from non-failing hearts, i.e. donor hearts not suitable for transplantation, and from severely failing hearts, i.e. explanted hearts of organ recipients, in order to identify possible alterations of the currents in cardiomyopathy. Human atrial myocytes were investigated for comparative(More)
BACKGROUND The cardiac calcium channel is known to be modulated by catecholamines via beta-adrenoceptors acting through intermediary GTP-binding regulatory proteins (G proteins). In biochemical studies on isolated membranes and reconstituted systems, it has been demonstrated that various G protein-coupled receptors, including beta-adrenoceptors, can(More)
The contribution of Na+, Ca2+, and various K+ currents to the shape of the cardiac action potential is outlined based on the relation between electrophysiological properties and structure of channel molecules. These currents have also been found in human ventricular myocytes, where the most prominent K+ current is a transient outward current that is not(More)
X-band ferromagnetic resonance (FMR) was used to characterize in-plane magnetic anisotropies in rectangular and square arrays of circular nickel and Permalloy microdots. In the case of a rectangular lattice, as interdot distances in one direction decrease, the in-plane uniaxial anisotropy field increases, in good agreement with a simple theory of(More)
In contrast to multispectral remote sensing data, airborne hyperspectral data showed to be highly suitable to identify areas of crop growth anomalies resulted from stress impact (e.g., nitrogen deficiency, fungal infections etc.) within agricultural plots. Resulting stress symptoms are changes in plant-physiology, whose characteristics affect the spectral(More)
The benefits and limitations of crop stress detection by hyperspectral data analysis have been examined in detail. It could thereby be demonstrated that even a differentiation between healthy and fungal infected wheat stands is possible and profits by analyzing entire spectra or specifically selected spectral bands/ranges. For reasons of practicability in(More)
Background. The cardiac calcium channel is known to be modulated by catecholamines via 1-adreno-ceptors acting through intermediary GTP-binding regulatory proteins (G proteins). In biochemical studies on isolated membranes and reconstituted systems, it has been demonstrated that various G protein-coupled receptors, including 3-adrenoceptors, can activate G(More)
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