Thorsten Hartmann

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Purpose. Lipid-water partitioning of 187 pharmaceuticals has been assessed with solid-supported lipid membranes (TRANSIL) in microwell plates and with multilamellar liposomes for a data comparison. The high-throughput potential of the new approach was evaluated. Methods. Drugs were incubated at pH 7.4 with egg yolk lecithin membranes either on a solid(More)
TROLL is a language particularly suited for the early stages of information system development, when the universe of discourse must be described. In TROLL the descriptions of the static and dynamic aspects of entities are integrated into object descriptions. Sublanguages for data terms, for first-order and temporal assertions, and for processes, are used to(More)
Conceptual modelling, sometimes in conjunction with requirements acquisition, is widely accepted as the rst formal step in information system speciication and design. Since knowledge about the world to be modelled is often vague in early development phases, formalisms for conceptual modelling must support a wide variety of concepts for describing real(More)
Sorting out new chemical entities (NCE) with inappropriate absorption, distribution, metabolism, excretion (ADME) behaviour at an early stage of drug discovery and development is a major challenge in pharmaceutical profiling. An accepted strategy to predict absorption is the measurement of the permeability of a drug candidate. One step earlier the(More)
In this paper, an approach to formally specify a conceptual model of a system and its environment to be developed in a behavior-oriented way is presented. We identify those concepts of object-oriented approaches that have to be formalized. We then propose characteristics of behavior-oriented mathematical models representing a system as a collection of(More)
Prototyping based on formal speciication should satisfy the requirements of engineers and users equally. The support of both groups requires a formalization of all activities as contract base and an increase of experience by experimental strategies. Contrary to these requirements several problems rest with existing software development environments, which(More)