Thorsten Braun

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We describe the characteristics and outcome of inflamma-tory arthritis in patients with myelodysplastic syndrome (MDS) in a French multicenter retrospective study. Twenty-two patients with MDS (median age, 77.5 yr Einterquartile range, 69Y81^; 10 women) were included. Inflammatory arthritis presented as polyarthritis in 17 cases (77%) and with symmetric(More)
The bromodomain (BRD) and extraterminal (BET) proteins including BRD2, BRD3 and BRD4 have been identified as key targets for leukemia maintenance. A novel oral inhibitor of BRD2/3/4, the thienotriazolodiazepine compound OTX015, suitable for human use, is available. Here we report its biological effects in AML and ALL cell lines and leukemic samples.(More)
The key to understanding changes in gene expression levels using reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR) relies on the ability to rationalize the technique using internal control genes (ICGs). However, the use of ICGs has become increasingly problematic given that any genes, including housekeeping genes, thought to(More)
The cytidine analogues azacytidine and 5-aza-2'-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic(More)
  • Heidi Oschmiansky, Thorsten Braun, Sten Emborg, Elsbeth Foged, Michael Gericke, Charlotte Hansen +21 others
  • 2002
In Denmark as in Germany the health care sector is coming increasingly under pressure: the ageing of the society will in the near future result in a drastic increase in the number people in need of care, while at the same time there is already a shortage of health professionals in some regions. Therefore the qualifications of health workers, as well as the(More)
During the preparation of Fig. 3A for the final version of this manuscript, the authors have assembled immunoblots from different cell lines without clearly indicating the borders between blots. A corrected version of Fig. 3A in which borders between blots are clearly indicated, with the loading controls for all the membranes subjected to immunoblot(More)
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