Thorsteinn Rögnvaldsson

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BACKGROUND Proteases of human pathogens are becoming increasingly important drug targets, hence it is necessary to understand their substrate specificity and to interpret this knowledge in practically useful ways. New methods are being developed that produce large amounts of cleavage information for individual proteases and some have been applied to extract(More)
The discrimination powers of Multilayer perceptron (MLP) and Learning Vector Quantisation (LVQ) networks are compared for overlapping Gaussian distributions. It is shown, both analytically and with Monte Carlo studies, that the MLP network handles high dimensional problems in a more eecient way than LVQ. This is mainly due to the sigmoidal form of the MLP(More)
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