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Huntington's disease (HD) is a hereditary neurodegenerative disease that leads to striatal degeneration and a severe movement disorder. We used a transgenic mouse model of HD (the R6/2 line with approximately 150 glutamine repeats) to test a new therapy for this disease. We treated HD mice with metformin, a widely used anti-diabetes drug, in the drinking(More)
The neurotoxicity of interleukin-6 (IL-6) and sodium nitroprusside (SNP, CAS 13755-38-9) was examined using primary cultures of rat hippocampal neurons. The cell viability was significantly reduced after the cultures were co-incubated with IL-6 4, 40, 400 ng/ml or SNP 1, 10, 100 mumol/l for 24 h. In addition, N omega-nitro-L-arginine (NNA, CAS 2149-70-4) at(More)
The effects of 20(S)-ginsenoside-Rg2 (GRg2, CAS 52286-74-5) and cyproheptadine (CYP, CAS 129-03-3) on acquisition, retention and retrieval were examined in male Wistar rats using a two-way active avoidance method. Learning and memory were estimated by the avoidance rate (%) and/or latency (s). Acute administration of CYP 1.0 mg/kg i.p. 30 min prior to(More)
We have developed a simple and sensitive assay to quantify neuron-specific death in primary cell cultures that represents a significant improvement over more commonly used methods including manual cell counting and lactate dehydrogenase release. This new method selectively detects neuronal death by combining immunolabeling for a neuron-specific marker with(More)
The effects of indometacin (CAS 53-86-1) on lipopolysaccharide-induced impairment of active avoidance and on interleukin-6-induced increase of prostaglandin E2 release were investigated in rats. In the experiment on acquisition and retention of one-way active avoidance in a shuttle box model, bilateral infusion of lipopolysaccharides (LPS) into the(More)
Using a multiple-trial, training-to-criterion procedure, the effects of repeated administrations of ginseng stem-leaves saponins (GSLS) on learning and memory of one-way avoidance in rats were studied in shuttle-box. In acquisition, GSLS 10, 30, and 60 mg.kg-1 ip shortened the latency of avoidance in a bell-shaped manner from 1.0 +/- 0.2 s in saline rats to(More)
Bilateral infusion of interleukin-6 (IL-6) 80 ng into the hippocampus has been shown to impair retention of a step-through passive avoidance task via shortening the step-through latency in testing. This infusion with IL-6 also increased the levels of nitrite and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in rat hippocampus. In addition,(More)
Protein bound and free 3-nitrotyrosine (3NT) levels are elevated in neurodegenerative diseases and have been used as evidence for peroxynitrite generation. Intrastriatal injection of free 3NT causes dopaminergic neuron injury and represents a new mouse model of Parkinson's disease (PD). We are investigating the nature of free 3NT neurotoxicity. In primary(More)
  • T C Ma, X Z Zhu
  • 1997
AIM To study the effect of intrahippocampal infusion of interleukin-6 (IL-6) on active avoidance in rats and the possible involvement of nitric oxide (NO). METHODS Using a shuttle-box model, the effects of bilaterally intrahippocampal infusion of IL-6 3.2, 16, and 80 ng as well as sodium nitroprusside (SNP) 400 ng on active avoidance were studied on d 8(More)
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