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This paper deals with an application of optimization in architectural design. Formally, we consider the problem of optimizing a function that can only be evaluated through an expensive oracle. We assume that the analytical expression of the function is unknown and first-order information is not available. This situation frequently occurs when each function(More)
Computational design tools in architecture currently fall into two broad categories: Tools for representation and tools for generative design, including scripting. However, both categories address only relatively methodical aspects of designing, and do little to support the design freedom and serendipitous creativity that, for example, is afforded by(More)
AIM The aim of the present study was to improve and confirm a time trial (TT) based method for determining anaerobic threshold (AnT) requiring minimal equipment. METHODS Eighteen participants underwent three to five all-out TTs for at the most 60 min. Velocity of the TTs was adapted in 0.1 or 0.2 m*s-1 steps until maximal velocity maintainable for at(More)
After emerging from a coma caused by enterohemorrhagic Escherichia coli (EHEC) sepsis with severe neurological and renal involvement a 53-year-old female patient complained of blurred vision. Due to hemolytic-uremic syndrome (HUS) the patient also suffered from dialysis-dependent acute kidney failure. Horizontal visual field defects of the lower hemifield(More)
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