Learn More
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions that trigger non-proteolytic ubiquitylation of adjacent chromatin areas to generate binding sites for DNA repair factors. This depends on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 (refs 1-6), and UBC13 (also known as UBE2N), an E2 ubiquitin-conjugating enzyme that(More)
During their biogenesis, 40S ribosomal subunit precursors are exported from the nucleus to the cytoplasm, where final maturation occurs. In this study, we show that the protein kinase human Rio2 (hRio2) is part of a late 40S preribosomal particle in human cells. Using a novel 40S biogenesis and export assay, we analyzed the contribution of hRio2 to late 40S(More)
This paper introduces a scalable hardware and software platform applicable for demonstrating the benefits of the invasive computing paradigm. The hardware architecture consists of a heterogeneous, tile-based manycore structure while the software architecture comprises a multi-agent management layer underpinned by distributed runtime and OS services. The(More)
The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and trans-acting factors are required for the ordered assembly of 40S and 60S ribosomal subunits. To date, only few human homologs of these yeast ribosome synthesis factors have(More)
The ever increasing complexity and heterogeneity of modern system-on-chip (SoC) architectures make an early and systematic exploration of alternative solutions mandatory. Efficient performance evaluation methods are of highest importance for a broad search in the solution space. In this paper we present an approach that captures the SoC functionality for(More)
In this paper, the MIMO framework within WINNER for fourth generation radio systems is further developed and assessed for various deployment scenarios. The emphasis is on radio network system aspects of multi-antenna techniques where preferred configurations for three basic deployment scenarios are given. In the wide area scenario which aims to provide(More)
In this paper, we present a new architectural concept for network processors called FlexPath NP. The central idea behind FlexPath NP is to systematically map network processor (NP) application sub-functions onto both SW programmable processor (CPU) resources and (re-)configurable HW building blocks, such that different packet flows are forwarded via(More)