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BACKGROUND & AIMS Interactions of neurotrophins with the appropriate trk receptors result in growth and maturational alterations in nervous system cells during development. The aim of this study was to examine whether similar interactions could be involved in human enteric nervous system (ENS) survival or differentiation as well. METHODS(More)
BACKGROUND/PURPOSE The diagnosis of intestinal neuronal dysplasia (IND) has traditionally been based on the finding of hyperplasia of the submucous plexus and increased acetylcholinesterase activity in parasympathetic nerve fibers in the lamina propria. However, recently it has been suggested that proposed diagnostic criteria relating to nerve cell density(More)
Interactions of the trk family of tyrosine kinase receptors with neurotrophins promote growth and differentiation of nervous-system cells during development. Disturbances in neurotrophic signalling could be involved in functional or aganglionic conditions of the intestine such as Hirschsprung's disease (HD). Intestinal resection specimens from 20 children(More)
Ebola is known to evade detection by the immune system during infection. In this paper, we use mathematical modeling as a tool to investigate and analyze the immune system dynamics in the presence of Ebola virus infection. The resulting model is a system of non-linear ordinary differential equations derived from known biological dynamics and a few(More)
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