Thomas Weller

Ralf Koberstein2
Catherine Brisbare-Roch2
François Jenck1
Joop van Gerven1
John Gatfield1
2Ralf Koberstein
2Catherine Brisbare-Roch
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  • Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui, Susan Flores +12 others
  • 2007
Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in orexinergic function is a pathophysiological hallmark of rodent, canine and human narcolepsy. Here we report that in rats, dogs and humans, somnolence is induced by pharmacological blockade of both orexin OX(1) and OX(2) receptors. When(More)
Replacement of the dimethoxyphenyl moiety in the core skeleton of almorexant by appropriately substituted imidazoles afforded novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as potent dual orexin receptor antagonists. We describe in this Letter our efforts to further optimize the potency and brain penetration of these derivatives by(More)
This paper presents a pulse-duration tunable Ultra-Wideband (UWB) generator that is developed using a variable edge-rate signal. Edge-rate variability is introduced by applying a step recovery diode (SRD) to compress the edges of the source and then employing a simple RC network to adjust the edge-rate. Afterwards, the compressed signal is differentiated(More)
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