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- A Labovsky, M Gunzburger, Juq, T Stephens, T Wanner, A Vladimirsky +47 others
- 2015

- Y Tanaka, S Engelender, S Igarashi, R K Rao, T Wanner, R E Tanzi +4 others
- Human molecular genetics
- 2001

Parkinson's disease (PD) is a common progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. Although mutations in alpha-synuclein have been identified in autosomal dominant PD, the mechanism by which dopaminergic neural cell death occurs remains unknown. Proteins encoded by two other genes in which… (More)

Phase separation processes in compound materials can produce intriguing and complicated patterns. Yet, characterizing the geometry of these patterns quantitatively can be quite challenging. In this paper we use computational algebraic topology to obtain such a characterization. Our method is illustrated for the complex microstructures observed during… (More)

Homology has long been accepted as an important computable tool for quantifying complex structures. In many applications these structures arise as nodal domains of real-valued functions and are therefore amenable only to a numerical study, based on suitable discretizations. Such an approach immediately raises the question of how accurate the resulting… (More)

We present an algorithm for computing the homology of inclusion maps which is based on the idea of coreductions and leads to significant speed improvements over current algorithms. It is shown that this algorithm can be extended to compute both persistent homology and an extension of the persistence concept to two-sided filtrations. In addition to… (More)

In this paper we present a new algorithm for computing the homology of regular CW-complexes. This algorithm is based on the coreduction algorithm due to Mrozek and Batko and consists essentially of a geometric preprocessing algorithm for the standard chain complex generated by a CW-complex. By employing the concept of S-complexes the original chain complex… (More)

This paper addresses the phenomenon of spinodal decomposition for the Cahn-Hilliard equation. Namely, we are interested in why most solutions to the Cahn-Hilliard equation which start near a homogeneous equilibrium u 0 in the spinodal interval exhibit phase separation with a characteristic wavelength when exiting a ball of radius R. There are two… (More)

This paper gives theoretical results on spinodal decomposition for the Cahn-Hillard equation. We prove a mechanism which explains why most solutions for the Cahn-Hilliard equation which start near a homogeneous equilibrium within the spinodal interval exhibit phase separation with a characteristic wavelength when exiting a ball of radius R. Namely, most… (More)

Homology has long been accepted as an important computational tool for quantifying complex structures. In many applications these structures arise as nodal domains of real-valued functions and are therefore amenable only to a numerical study based on suitable discretizations. Such an approach immediately raises the question of how accurately the resulting… (More)

The quasigeostrophic model is a simplified geophysical fluid model at asymptotically high rotation rate or at small Rossby number. We consider the quasigeostrophic equation with dissipation under random forcing in bounded domains. We show that global unique solutions exist for appropriate initial data. Unlike the deterministic quasi-geostrophic equation… (More)