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The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract An off-policy Bayesian nonparameteric approximate reinforcement learning framework, termed as GPQ, that employs a Gaussian Processes (GP) model of the value (Q) function is presented in both the batch and online settings.(More)
Traditionally, operating systems use a coarse approximation of memory accesses to implement memory management algorithms by monitoring page faults or scanning page table entries. With finer-grained memory access information, however, the operating system can manage memory muchmore effectively. Previous work has proposed the use of a software mechanism based(More)
BACKGROUND Post-transcriptional regulation in eukaryotes can be operated through microRNA (miRNAs) mediated gene silencing. MiRNAs are small (18-25 nucleotides) non-coding RNAs that play crucial role in regulation of gene expression in eukaryotes. In insects, miRNAs have been shown to be involved in multiple mechanisms such as embryonic development, tissue(More)
The pathways that allow short noncoding RNAs such as the microRNAs (miRNAs) to mediate gene regulation and control critical cellular and developmental processes involve a limited number of key protein components. These proteins are the Dicer-like RNases, double-stranded RNA (dsRNA)-binding proteins, and the Argonaute (AGO) proteins that process stem-loop(More)
  • Wee Tek Tay, Miguel F. Soria, Thomas Walsh, Danielle Thomazoni, Pierre Silvie, Gajanan T. Behere +2 others
  • 2013
The highly polyphagous Old World cotton bollworm Helicoverpa armigera is a quarantine agricultural pest for the American continents. Historically H. armigera is thought to have colonised the American continents around 1.5 to 2 million years ago, leading to the current H. zea populations on the American continents. The relatively recent species divergence(More)
Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and after 4 months of neoadjuvant aromatase inhibitor (NAI)(More)
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