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The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans. In this study, we examined the absorption, bioavailability, and metabolism(More)
BACKGROUND Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are(More)
We present the most recent version of our RoboCube system, a special robot-controller hand-tailored for players in the small robots league. The RoboCube is conceptualized to implement players with as many on-board features as possible in an extremely exible way. For this purpose, the RoboCube provides quite some computation power and memory as well as a(More)
The paper describes the VUB AI-Lab team competing in the small robots league of RoboCup '98 in Paris. The approach of this team targets for a longterm evolution of diierent robots, team-structures, and concepts. Therefore, the eeorts for the '98 participation focus providing a exible architecture, which forms a basis for this goal. In doing so, the(More)
The VUB AI-lab team is mainly interested in the two loosely linked aspects of on-board control and heterogeneity. One major eeort for fostering both aspects within RoboCup's small robots league is our development of a so-to-say robot construction-kit, allowing to implement a wide range of players with on-board control. For the '99 competition, the existing(More)
The objective of this study was to examine the ability of dietary polyphenols to inhibit cytochrome P450 (CYP) 1A1 expression and activity and benzo[a]pyrene (BaP) DNA binding, with the main emphasis on prevention of chemical-induced hepatic carcinogenesis. For this purpose we used Hep G2 cells, a good model of the normal human hepatocyte for CYP1A1 cell(More)
Evidence has accumulated that dietary polyphenols, in particular, flavonoids, have protective effects against oral cancer. In this study, we have examined the effects of quercetin, a major dietary flavonoid, on cell growth and necrosis/apoptosis and cell cycle regulation in human oral squamous carcinoma SCC-9 cells. Quercetin induced dose- and(More)
Dietary flavones have promising chemoprotective properties, in particular with regard to cancer, but problems with low oral bioavailability and sometimes unacceptable toxicity have made their use as protective additives to normal diets questionable. However, methylation of free phenolic hydroxyl groups leads to derivatives not susceptible to glucuronic acid(More)