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The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans. In this study, we examined the absorption, bioavailability, and metabolism(More)
Ellagic acid (EA), a polyphenol present in berries, has been demonstrated to be preventive of esophageal and colon cancer in animals. Here, we have studied the ability of organic anion transporters (OATs) and organic anion-transporting polypeptides (OATPs) to transport EA. The accumulation of radiolabeled (14)C]EA, [(3)H]p-aminohippuric acid (PAH),(More)
BACKGROUND Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are(More)
We present the most recent version of our RoboCube system, a special robot-controller hand-tailored for players in the small robots league. The RoboCube is conceptualized to implement players with as many on-board features as possible in an extremely exible way. For this purpose, the RoboCube provides quite some computation power and memory as well as a(More)
The paper describes the VUB AI-Lab team competing in the small robots league of RoboCup '98 in Paris. The approach of this team targets for a longterm evolution of diierent robots, team-structures, and concepts. Therefore, the eeorts for the '98 participation focus providing a exible architecture, which forms a basis for this goal. In doing so, the(More)
(-)-Epicatechin gallate (ECG) is one of the flavonoids in green tea, which has been demonstrated to have cancer-preventive properties in many model systems. However, the extent and mechanisms of accumulation of these flavonoids in cells is unknown. The objectives of this study were to determine the accumulation of ECG by the intestinal epithelial cell(More)
To better understand the relationship between the chemical structure and biological fate of dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated polyphenols, in comparison with unmethylated polyphenols, were investigated in pooled human liver S9 fraction and human colon adenocarcinoma (Caco-2) cells. Consistent with(More)
Estrogen sulfotransferase (EST) is the sole sulfotransferase expressed in normal human breast epithelial cells and has an important function in determining free estrogen hormone levels in these cells. In the present study we examined the inhibitory effect of the dietary polyphenols quercetin and resveratrol on EST activity, i.e. 17beta-estradiol (E2)(More)
We present a fast shared memory multiprocessor with uniform memory access time. A rst prototype (SB{PRAM) is running with 4 processors, a 128 processor version is under construction. A second implementation (HPP) using latest VLSI technology and optical links shall run at a speed of 96 MHz. To a c hieve this speed, we rst investigate the redesign of ASICs(More)
Cooked food mutagens from fried meat and fish have recently been suggested to contribute to the etiology of breast cancer. Thus, the most prevalent of these compounds, i.e. 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, or rather its more mutagenic N-hydroxylated metabolite (N-OH-PhIP), forms DNA adducts in mammary cells, including human mammary(More)