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The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans. In this study, we examined the absorption, bioavailability, and metabolism(More)
BACKGROUND Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are(More)
Estrogen sulfotransferase (EST) is the sole sulfotransferase expressed in normal human breast epithelial cells and has an important function in determining free estrogen hormone levels in these cells. In the present study we examined the inhibitory effect of the dietary polyphenols quercetin and resveratrol on EST activity, i.e. 17beta-estradiol (E2)(More)
We present the most recent version of our RoboCube system, a special robot-controller hand-tailored for players in the small robots league. The RoboCube is conceptualized to implement players with as many on-board features as possible in an extremely exible way. For this purpose, the RoboCube provides quite some computation power and memory as well as a(More)
The paper describes the VUB AI-Lab team competing in the small robots league of RoboCup '98 in Paris. The approach of this team targets for a longterm evolution of diierent robots, team-structures, and concepts. Therefore, the eeorts for the '98 participation focus providing a exible architecture, which forms a basis for this goal. In doing so, the(More)
The VUB AI-lab team is mainly interested in the two loosely linked aspects of on-board control and heterogeneity. One major eeort for fostering both aspects within RoboCup's small robots league is our development of a so-to-say robot construction-kit, allowing to implement a wide range of players with on-board control. For the '99 competition, the existing(More)
Evidence has accumulated that dietary polyphenols, in particular, flavonoids, have protective effects against oral cancer. In this study, we have examined the effects of quercetin, a major dietary flavonoid, on cell growth and necrosis/apoptosis and cell cycle regulation in human oral squamous carcinoma SCC-9 cells. Quercetin induced dose- and(More)
The objective of this study was to examine the ability of dietary polyphenols to inhibit cytochrome P450 (CYP) 1A1 expression and activity and benzo[a]pyrene (BaP) DNA binding, with the main emphasis on prevention of chemical-induced hepatic carcinogenesis. For this purpose we used Hep G2 cells, a good model of the normal human hepatocyte for CYP1A1 cell(More)
Previous studies have shown chrysin, 7-hydroxyflavone and 7,4'-dihydroxyflavone to be the most potent flavonoid inhibitors of aromatase. However, very poor oral bioavailability is a major limitation for the successful use of dietary flavonoids as chemopreventive agents. We have recently shown that methylated flavones, including 5,7-dimethoxyflavone,(More)