Thomas W Doebber

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PPAR gamma is an adipocyte-specific nuclear hormone receptor. Agonists of PPAR gamma, such as thiazolidinediones (TZDs), promote adipocyte differentiation and have insulin-sensitizing effects in animals and diabetic patients. Affymetrix oligonucleotide arrays representing 6347 genes were employed to profile the gene expression responses of mature 3T3-L1(More)
Peroxisome proliferator-activated receptor (PPAR)-␥ ago-nists are insulin sensitizers, whereas PPAR␣ agonists are lip-id-lowering agents in humans. Chronic treatment with PPAR␥ agonists has been shown to prevent the onset of diabetes in young Zucker diabetic fatty (ZDF) rats; however, the effects of PPAR␣ agonists have not been well characterized in this(More)
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