Learn More
The DDB2 gene, which is mutated in xeroderma pigmentosum group E, enhances global genomic repair of cyclobutane pyrimidine dimers and suppresses UV-induced mutagenesis. Because DDB2 transcription increases after DNA damage in a p53-dependent manner, we searched for and found a region in the human DDB2 gene that binds and responds transcriptionally to p53.(More)
With the increasing demand of software capabilities in both business and government operations, building trustworthy software become critical for the success of the organization. However, the growth of Internet throws different kinds of malicious and/or unintentional threats into the mix by providing endless points of attacks that threatens the dependency(More)
This study was designed to assess the effects of aspirin on arylamine N-acetyltransferase (NAT) activities in the bacterium Klebsiella pneumoniae using high performance liquid chromatography to measure the acetylation of 2-aminofluorene (2-AF) with or without aspirin. Cytosols or suspensions of K. pneumoniae with or without specific concentrations of(More)
We investigated the mechanisms of MDR1 gene activation by CCAAT/enhancer binding protein beta (C/EBPbeta, or nuclear factor for interleukin 6) in human cancer cells. Transfection of the breast cancer cell line MCF-7 and its doxorubicin-selected variant MCF-7/ADR by either C/EBPbeta or C/EBPbeta-LIP (a dominant-negative form of C/EBPbeta) confirmed their(More)
It is well known that N-acetyltransferase (NAT) plays an important role in the arylamine metabolism. We analysed the response of A549 human lung cancer cells for N-acetylation of 2-aminofluorene (AF) to curcumin. After curcumin treatment, the NAT activity was examined by HPLC, AF-DNA adduct formation was examined by HPLC, and NAT gene expression by(More)
UNLABELLED Hepatitis B virus (HBV) is a small DNA virus that requires cellular transcription factors for the expression of its genes. To understand the molecular mechanisms that regulate HBV gene expression, we conducted a yeast one-hybrid screen to identify novel cellular transcription factors that may control HBV gene expression. Here, we demonstrate that(More)
Clavibacter michiganensis subsp. michiganensis (CMM), the causal agent of bacterial canker of tomato, is a quarantine organism in many countries. In this study, a one-step method was developed for the detection of CMMs in symptomless tomato seeds directly using a TaqMan probe. The absolute sensitivity threshold was approximately 10 CFU/ml. In seeds the(More)
In an investigating study to trace the productivity changes of a commercial software project, which uses incremental and iterative development model, we've found evidence that attributes such as staffing stability, design compatibility/ adaptability to incremental and iterative development, and integration and testing would have significant impact on(More)
For a software project to succeed, acceptable quality must be achieved within an acceptable cost, providing business value to the customers, and keeping delivery time short. Software testing is a strenuous and expensive process and is often not organized to maximize business value. In this article, we propose a practical value based software testing method(More)