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Recent compelling evidence has lead to renewed interest in the role of antibodies and immune complexes in the pathogenesis of several autoimmune disorders, such as rheumatoid arthritis. These immune complexes, consisting of autoantibodies to self-antigens, can mediate inflammatory responses largely through binding and activating the immunoglobulin Fc(More)
Genome integrity is jeopardized each time DNA replication forks stall or collapse. Here we report the identification of a complex composed of MMS22L (C6ORF167) and TONSL (NFKBIL2) that participates in the recovery from replication stress. MMS22L and TONSL are homologous to yeast Mms22 and plant Tonsoku/Brushy1, respectively. MMS22L-TONSL accumulates at(More)
PURPOSE Mantle-cell lymphoma (MCL) has a variable natural history but is incurable with current therapies. MicroRNAs (miRs) are useful in prognostic assessment of cancer. We determined an miR signature defining aggressiveness in B-cell non-Hodgkin lymphomas (NHL) and assessed whether this signature aids in MCL prognosis. METHODS We assessed miR expression(More)
Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1 in luminal BC cells was shown to affect response to endocrine, radiation and several antineoplastic drugs.(More)
This paper reports on the development of a flexible 5-MBd equalized M-QAM testbed for high-speed wireless data communications. The unit operates in real time and was field tested in typical indoor environments. A total of 3600 independent experiments were conducted using the testbed where one of 4-, 16-, 64-QAM constellations were transmitted, and the(More)
Triple-negative breast cancer (TNBC) represents an aggressive subtype, for which radiation and chemotherapy are the only options. Here we describe the identification of disulfiram, an FDA-approved drug used to treat alcoholism, as well as the related compound thiram, as the most potent growth inhibitors following high-throughput screens of 3185 compounds(More)
We have used small-angle neutron scattering to characterize the polymer conformations of four nonionic water soluble polymers: poly~ethylene oxide!, poly~N-vinyl-2-pyrollidone!, poly~N-vinyl-2-caprolactam!, and an N-methyl, N-vinylacetamide/N-vinyl-2-caprolactam copolymer. The last three of these are able to kinetically suppress hydrate crystallization, and(More)
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